Key publications-Faculty
Menu E and Vanderkerken K, (2022) Exosomes: from bench to bedside, Blood, https://doi.org/10.1182/blood.2021014749.
Oudaert I; Satilmis H; Vlummens P; ....Vanderkerken K; De Veirman K; Menu E. (2022) Pyrroline-5-Carboxylate Reductase 1: a novel target for sensitizing multiple myeloma cells to bortezomib by inhibition of PRAS40-mediated protein synthesis. Journal of Experimental & Clinical Cancer Research, https://doi.org/10.1186/s13046-022-02250-3
Maes, A., Maes, K., De Raeve, H., De Smedt, E., Vlummens, P., Szablewski, V., ... De Bruyne, E. (2019). The anaphase-promoting complex/cyclosome: a new promising target in diffuse large B-cell lymphoma and mantle cell lymphoma. British Journal of Cancer, 120(12), 1137-1146. https://doi.org/10.1038/s41416-019-0471-0
De Smedt, E., Maes, K., Verhulst, S., Liu, H., Kassambara, A., Maes, A., ... De Bruyne, E. (2018). Loss of RASSF4 expression in multiple myeloma promotes RAS-driven malignant progression. Cancer Research, 78(5), 1155-1168. https://doi.org/10.1158/0008-5472.CAN-17-1544
De Veirman, K., De Beule, N., Maes, K., Menu, E., De Bruyne, E., De Raeve, H., ... Van Valckenborgh, E. (2017). Extracellular S100A9 protein in bone marrow supports multiple myeloma survival by stimulating angiogenesis and cytokine secretion. Cancer Immunology Research, 5(10), 839-846. https://doi.org/10.1158/2326-6066.CIR-17-0192
Favreau, M., Menu, E., Gaublomme, D., Vanderkerken, K., Faict, S., Maes, K., ... Elewaut, D. (2017). Leptin receptor antagonism of iNKT cell function: a novel strategy to combat multiple myeloma. Leukemia, 31(12), 2678-2685. https://doi.org/10.1038/leu.2017.146
Frassanito, M., De Veirman, K., Desantis, V., Marzo, L. D., Vergara, D., Ruggieri, S., ... Vacca, A. (2016). Halting pro-survival autophagy by TGFβ inhibition in bone marrow fibroblasts overcomes bortezomib resistance in multiple myeloma patients. Leukemia, 30(3), 640-648. https://doi.org/10.1038/leu.2015.289
Wang, J., Hendrix, A., Hernot, S., Lemaire, M., De Bruyne, E., Van Valckenborgh, E., ... Menu, E. (2014). Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells. Blood, 124(4), 555-566.
De Bruyne, E., Bos, T., Schuit, F., Van Valckenborgh, E., Menu, E., Thorrez, L., ... Vanderkerken, K. (2010). IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms. Blood, 115(12), 2430-2440.